Synaptic Specializations Support Frequency-Independent Purkinje Cell Output from the Cerebellar Cortex.
Cell Rep. 2016 Dec 20;17(12):3256-3268
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摘要
-receptor saturation occurs at this synapse but does not underlie frequency-invariant transmission. We propose that PC-DCN synapses have two components of release: one prominent early in trains and another specialized to maintain transmission during prolonged activation. Short-term facilitation offsets partial vesicle depletion to produce frequency-independent transmission.
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