Caspase-2-mediated cell death is required for deleting aneuploid cells.
Oncogene. 2017 May 11;36(19):2704-2714. Epub 2016 Dec 19
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摘要
mutant mice to demonstrate that caspase-2 catalytic activity is essential for its function in limiting aneuploidy. Our results provide direct evidence that the apoptotic activity of caspase-2 is necessary for deleting cells with mitotic aberrations to limit aneuploidy.
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基因功能
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原始数据
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文献解读
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