PKA-RIIB Deficiency Induces Brown Fatlike Adipocytes in Inguinal WAT and Promotes Energy Expenditure in Male FVB/NJ Mice.

Obesity has become the most common metabolic disorder worldwide. Promoting brown adipose tissue (BAT) and beige adipose tissue formation, and therefore, a functional increase in energy expenditure, may counteract obesity. Mice lacking type IIβ regulatory subunit of adenosine 3',5' cyclic monophosphate (cAMP)-dependent protein kinase A display reduced adiposity and resistance to diet-induced obesity. encoded by the Prkar2b gene, is most abundant in BAT and white adipose tissue (WAT) and in the brain. In this study, we show that mice lacking have increased energy expenditure, limited weight gain, and improved glucose metabolism. duanyu1529-RIIB deficiency induces brownlike adipocyte in inguinal WAT (iWAT). duanyu1529-RIIB deficiency also increases the expression of uncoupling protein 1 and other thermogenic genes in iWAT and primary preadipocytes from iWAT through a mechanism involving increased activity, which is represented by increased phosphorylation of duanyu1529 substrate, cAMP response element binding protein, and P38 mitogen-activated protein kinase. Our study provides evidence for the role of duanyu1529-RIIB deficiency in regulating thermogenesis in WAT, which may potentially have therapeutic implications for the treatment of obesity and related metabolic disorders.

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