Cosmc is an X-linked inflammatory bowel disease risk gene that spatially regulates gut microbiota and contributes to sex-specific risk.
Proc. Natl. Acad. Sci. U.S.A.2016 Dec 20;113(51):14787-14792. Epub 2016 Dec 07
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摘要
) were protected from spontaneous inflammation and partially protected from experimental colitis, likely due to lateral migration of normal mucin glycocalyx from WT cells over KO crypts. These studies functionally validate Cosmc as an IBD risk factor and implicate it in regulating the spatial pattern of dysbiosis and sex bias in IBD.
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基因功能
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原始数据
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文献解读
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