MYD88, CD79B, and CARD11 gene mutations in CD5-positive diffuse large B-cell lymphoma.

BACKGROUND:DLBCL and DLBCL-SS. METHODS:DLBCL. Mutation analysis was performed by direct sequencing. RESULTS:DLBCL. Ten patients had these 2 gene mutations, and 1 had a CD79A mutation. One of 2 patients with testicular involvement had both MYD88 and CD79B mutations. The other patient had a MYD88 mutation alone. None of the 31 patients examined was found to have a CARD11 mutation. MYD88 and CD79B mutations were found to be associated with localized disease (P = .038 and P = .003, respectively). Primary extranodal lymphoma was associated with higher frequencies of mutations in MYD88 or both MYD88 and CD79B (P = .008 and P = .014, respectively). There was no significant difference in overall survival based on MYD88 and CD79B mutation status. CONCLUSIONS:DLBCL. Cancer 2017;123:1166-1173. © 2016 American Cancer Society.

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