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Angiopoietin-related growth factor is independently associated with lower extremity peripheral arterial disease.

J. Diabetes Complicat.2017 Feb;31(2):433-438. Epub 2016 Oct 27
Hao Nie 1 , Yue Liang 1 , Hong-Xia Wang 2 , Hua-Liang Ren 1 , Yue-Wei Wang 1 , Fang-Da Li 1 , Yue-Hong Zheng 3
Hao Nie 1 , Yue Liang 1 , Hong-Xia Wang 2 , Hua-Liang Ren 1 , Yue-Wei Wang 1 , Fang-Da Li 1 , Yue-Hong Zheng 3
+ et al

[No authors listed]

Author information
  • 1 Department of Vascular Surgery, Peking Union Medical Hospital, Beijing, 100000, PR China.
  • 2 Department of Physiology and Physiopathology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100000, PR China.
  • 3 Department of Vascular Surgery, Peking Union Medical Hospital, Beijing, 100000, PR China. Electronic address: yuehongzheng@yahoo.com.

摘要


AIMS:The present study investigated the association of serum levels of angiopoietin-related growth factor (AGF) with lower extremity peripheral arterial disease study group is comprised of 105 patients with lower extremity peripheral arterial disease. The control group consisted of 80 individuals without lower extremity peripheral arterial disease. Serum AGF concentrations were determined by enzyme-linked immunosorbent assay. The relationship between AGF and clinical and biochemical parameters was studied. Besides, this study analyzed AGF levels in patients according to disease severity and evaluated the prognostic value of AGF for amputation and mortality in LEduanyu1563 patients after a follow-up period of 1.7years. RESULTS:Median serum AGF levels were significantly higher in LEduanyu1563 group (103.70±64.69ng/mL) as compared with control group (53.83±37.87ng/mL) (P<0.001). In addition, T2DM patients with LEduanyu1563 exhibited markedly higher serum AGF concentrations (118.7±60.90ng/mL) than those without LEduanyu1563 (60.23±32.62ng/mL) (P<0.0001). Moreover, LEduanyu1563 positively predicted AGF concentrations in multivariate linear regression analysis (P<0.0001). Serum AGF levels were independently associated with LEduanyu1563 in binary logistic regression analysis model. Among LEduanyu1563 patients, those with critical limb ischemia (n=43) showed higher AGF levels (124.9±73.9 vs. 88.98±53.26ng/mL, P=0.01) compared with those with intermittent claudication (n=62). Furthermore, patients with the highest AGF tertile had an increased all-cause mortality and cardiovascular mortality (P=0.033 and P=0.025, respectively). CONCLUSIONS:Our results suggested that lower extremity peripheral artery disease was positively associated with AGF serum levels. High serum AGF level was a potential risk factor for LEduanyu1563 and associates with disease severity and poor outcome in LEduanyu1563 patients.

KEYWORDS: Angiogenic factor, Angiopoietin-related growth factor, Lower extremity, Peripheral artery disease, Type 2 diabetes mellitus