The protein-tyrosine phosphatase DEP-1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase.
Glia. 2017 Feb;65(2):416-428. doi:10.1002/glia.23100. Epub 2016 Nov 17
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摘要
mice in vivo. Taken together our data revealed a previously unrecognized role of DEP-1 and suggest the existence of a potential DEP-1-Fyn axis in the regulation of microglial functions. GLIA 2017;65:416-428.
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文献解读
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