Intronless WNT10B-short variant underlies new recurrent allele-specific rearrangement in acute myeloid leukaemia.
Sci Rep. 2016 Nov 17;6:37201
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摘要
. Chemical interference of WNT-ligands production by the porcupine inhibitor IWP-2 achieved a dose-dependent suppression of the WNT10B-FZD4/5 interactions. These results present the first evidence for a recurrent rearrangement promoted by a mobile ht-WNT10B oncogene, as a relevant mechanism for Wnt involvement in human cancer.
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基因功能
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原始数据
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文献解读
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