Polymorphism of SLC6A2 gene does not influence outcome of myocardial ¹²³I-mIBG scintigraphy in patients with chronic heart failure.

AIM:The NET, encoded by SLC6A2, is responsible for presynaptic NE-reuptake. ¹²³I-mIBG is clinically used to evaluate cardiac sympathetic function. However, it is unknown if polymorphism of SLC6A2 influences cardiac sympathetic activity as assessed with ¹²³I-mIBG. Therefore we studied the influence of SLC6A2 SNPs on myocardial ¹²³I-mIBG parameters in CHF. MATERIALS AND METHODS:Forty-nine adults with stable CHF (age 66.5 ± 8.1 years, LVEF 22.3 ± 6.4) were enrolled. Fifteen minutes (early) and 4 hours (late) after administration of ¹²³I-mIBG planar images were acquired. The H/M ratio was calculated from the manually drawn ROI over the left ventricle and a fixed mediastinal ROI. Fourteen exons of the SLC6A2 gene were analyzed from whole blood samples. RESULTS:We found 6 different SLC6A2 SNPs, although none were functional. LVEF was the only independent predictor for early (adjusted R ²Â = 0.063, p = 0.045) and late H/M ratio (adjusted R ²Â = 0.116, p = 0.010). NT-proBNP was the only independent predictor for ¹²³I-mIBG WO (adjusted R ²Â = 0.074, p = 0.032). SLC6A2 SNPs were not associated with any myocardial ¹²³I-mIBG-derived parameter. CONCLUSION:In this specific CHF population polymorphism of SLC6A2 gene was not associated with any ¹²³I-mIBG derived parameters.

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