Emulating proton-induced conformational changes in the vesicular monoamine transporter VMAT2 by mutagenesis.
Proc. Natl. Acad. Sci. U.S.A.2016 Nov 22;113(47):E7390-E7398. Epub 2016 Nov 07
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摘要
-coupled antiporter, and also identify key aspects of the mode of action and binding of two potent inhibitors of VMAT2: reserpine binds the cytoplasm-facing conformation, and tetrabenazine binds the lumen-facing conformation.
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基因功能
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原始数据
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文献解读
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