Glucose tolerance female-specific QTL mapped in collaborative cross mice.

Mamm. Genome. 2017 Feb;28(1-2):20-30. Epub 2016 Nov 02

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trait, located on Chromosome 8 (32-34.5 Mbp, containing 51 genes). Gene browse revealed QTL for body weight/size, genes involved in immune system, and two main protein-coding genes involved in the Glucose homeostasis, Mboat4 and Leprotl1. Heritability and coefficient of genetic variance (CVg) were 0.49 and 0.31 for females, while for males, these values 0.34 and 0.22, respectively. Our findings demonstrate the roles of genetic factors controlling glucose tolerance, which significantly differ between sexes requiring independent studies for females and males toward T2D prevention and therapy.

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Glucose tolerance female-specific QTL mapped in collaborative cross mice.

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