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PLC-β1 and cell differentiation: An insight into myogenesis and osteogenesis.

Adv Biol Regul. 2016 Oct 18. Epub 2016 Oct 18
Giulia Ramazzotti 1 , Irene Faenza 2 , Roberta Fiume 2 , Anna Maria Billi 2 , Lucia Manzoli 2 , Sara Mongiorgi 2 , Stefano Ratti 2 , James A McCubrey 3 , Pann-Ghill Suh 4 , Lucio Cocco 2 , Matilde Y Follo 2
Giulia Ramazzotti 1 , Irene Faenza 2 , Roberta Fiume 2 , Anna Maria Billi 2 , Lucia Manzoli 2 , Sara Mongiorgi 2 , Stefano Ratti 2 , James A McCubrey 3 , Pann-Ghill Suh 4 , Lucio Cocco 2 , Matilde Y Follo 2
+ et al

[No authors listed]

Author information
  • 1 Cellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy. Electronic address: giulia.ramazzotti@unibo.it.
  • 2 Cellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
  • 3 Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, USA.
  • 4 Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.

摘要


Phosphoinositide-phospholipase C-β1 (PLC-β1) plays a crucial role in the initiation of the genetic program responsible for muscle differentiation and osteogenesis. During myogenic differentiation of murine C2C12 myoblasts, PLC-β1 signaling pathway involves the Inositol Polyphosphate Multikinase (IPMK) and β-catenin as downstream effectors. By means of c-jun binding to cyclin D3 promoter, the activation of PLC-β1 pathway determines cyclin D3 accumulation. However, osteogenesis requires PLC-β1 expression and up-regulation but it does not affect cyclin D3 levels, suggesting that the two processes require the activation of different mediators.