RhoH is a negative regulator of eosinophilopoiesis.
Cell Death Differ.2016 Dec;23(12):1961-1972. Epub 2016 Oct 14
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摘要
mice, we observed reduced GATA-2 expression as well as accelerated eosinophil differentiation both in vitro and in vivo. Conversely, RhoH overexpression in bone marrow progenitors reduces eosinophil development in mixed bone marrow chimeras. These results highlight a novel negative regulatory role for RhoH in eosinophil differentiation, most likely in consequence of altered GATA-2 levels.
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文献解读
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