例如："lncRNA", "apoptosis", "WRKY"

HB-GAM (pleiotrophin) reverses inhibition of neural regeneration by the CNS extracellular matrix.

Sci Rep. 2016 Sep 27;6:33916
Mikhail Paveliev 1 , Keith K Fenrich 2 , Mikhail Kislin 1 , Juha Kuja-Panula 1 , Evgeny Kulesskiy 1 , Markku Varjosalo 3 , Tommi Kajander 3 , Ekaterina Mugantseva 1 , Anni Ahonen-Bishopp 1 , Leonard Khiroug 1 , Natalia Kulesskaya 1 , Geneviève Rougon 4 , Heikki Rauvala 1
Mikhail Paveliev 1 , Keith K Fenrich 2 , Mikhail Kislin 1 , Juha Kuja-Panula 1 , Evgeny Kulesskiy 1 , Markku Varjosalo 3 , Tommi Kajander 3 , Ekaterina Mugantseva 1 , Anni Ahonen-Bishopp 1 , Leonard Khiroug 1 , Natalia Kulesskaya 1 , Geneviève Rougon 4 , Heikki Rauvala 1
+ et al

[No authors listed]

Author information
  • 1 Neuroscience Center, University of Helsinki, Finland.
  • 2 Neuroscience and Mental Health Institute, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada.
  • 3 Institute of Biotechnology, University of Helsinki, Finland.
  • 4 Neuroscience Institute Marseille, France.
全文

摘要

Chondroitin sulfate (CS) glycosaminoglycans inhibit regeneration in the adult central nervous system (CNS). We report here that HB-GAM (heparin-binding growth-associated molecule; also known as pleiotrophin), a CS-binding protein expressed at high levels in the developing CNS, reverses the role of the CS chains in neurite growth of CNS neurons in vitro from inhibition to activation. The CS-bound HB-GAM promotes neurite growth through binding to the cell surface proteoglycan glypican-2; furthermore, HB-GAM abrogates the CS ligand binding to the inhibitory receptor PTPσ (protein tyrosine phosphatase sigma). Our in vivo studies using two-photon imaging of CNS injuries support the in vitro studies and show that HB-GAM increases dendrite regeneration in the adult cerebral cortex and axonal regeneration in the adult spinal cord. Our findings may enable the development of novel therapies for CNS injuries.

图表

© 2017 biocloud.net版权所有 ICP证：京10042835号