ADAMTS13 deficiency promotes microthrombosis in a murine model of diet-induced liver steatosis.

Thromb. Haemost.2017 Jan 05;117(1):19-26. Epub 2016 Sep 08

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mice) without differences between the genotypes. Expression of markers of inflammation, oxidative stress, steatosis and fibrosis was affected by diet, but not by genotype. Thus, our data confirm that obesity promotes NASH, but do not support a detrimental role of ADAMTS13 in its development. However, Adamts13 deficiency in obese mice promotes hepatic microthrombosis, whereas a compensatory role of plasmin in removal of microthrombi in the absence of ADAMTS13 could not be demonstrated.

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ADAMTS13 deficiency promotes microthrombosis in a murine model of diet-induced liver steatosis.

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