Design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors.

Bioorg. Med. Chem. Lett.2016 Sep 15;26(18):4492-4496. Epub 2016 Jul 29

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Features from a high throughput screening (HTS) hit and a previously reported scaffold were combined to generate 1,7-naphthyridones as novel KDM5 enzyme inhibitors with nanomolar potencies. These molecules exhibited high selectivity over the related KDM4C and KDM2B isoforms. An X-ray co-crystal structure of a representative molecule bound to KDM5A showed that these inhibitors are competitive with the co-substrate (2-oxoglutarate or 2-OG).

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Design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors.

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