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CATCHR, HOPS and CORVET tethering complexes share a similar architecture.

Nat. Struct. Mol. Biol.2016 Aug;23(8):761-3. Epub 2016 Jul 18
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摘要


We show here that the Saccharomyces cerevisiae complex and the Cog1-4 subcomplex of the COG complex, both members of the complexes associated with tethering containing helical rods (CATCHR) family of multisubunit tethering complexes, share the same subunit organization. We also show that HOPS, a tethering complex acting in the endolysosomal pathway, shares a similar architecture, thus suggesting that multisubunit tethering complexes use related structural frameworks.

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