A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines.
Nat. Chem. Biol.2016 Sep;12(9):669-71. Epub 2016 Jul 11
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摘要
More than 30 years ago, a calcium-dependent enzyme activity was described that generates N-acyl phosphatidylethanolamines (NAPEs), which are precursors for N-acyl ethanolamine (NAE) lipid transmitters, including the endocannabinoid anandamide. The identity of this calcium-dependent N-acyltransferase (Ca-NAT) has remained mysterious. Here, we use activity-based protein profiling to identify the poorly characterized serine hydrolase PLA2G4E as a mouse brain Ca-NAT and show that this enzyme generates NAPEs and NAEs in mammalian cells.
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基因功能
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原始数据
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文献解读
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