Serum amyloid A regulates monopoiesis in hyperlipidemic Ldlr(-/-) mice.
FEBS Lett.2016 Aug;590(16):2650-60. doi:10.1002/1873-3468.12269. Epub 2016 Jul 08
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摘要
We previously showed that feeding a Western-type diet (WTD) to Ldlr(-/-) mice lacking serum amyloid A (SAA) (Saa(-/-) Ldlr(-/-) mice), the level of total blood monocytes was higher than in Ldlr(-/-) mice. In this investigation we demonstrate that higher levels of bone marrow monocytes and macrophage-dendritic cell progenitor (MDP) cells were found in WTD-fed Saa(-/-) Ldlr(-/-) mice compared to Ldlr(-/-) mice and lower levels of GMP cells and CMP cells in Ldlr(-/-) mice. These data indicate that SAA regulates the level of bone marrow monocytes and their myeloid progenitors in hyperlipidemic Ldlr(-/-) mice.
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基因功能
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原始数据
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文献解读
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