SPANXA suppresses EMT by inhibiting c-JUN/SNAI2 signaling in lung adenocarcinoma.

(Sperm Protein Associated with the Nucleus on the X-chromosome, family members A1/A2) acts as a cancer-testis antigen expressed in normal testes, but dysregulated in various tumors. We found that duanyu1842NXA is highly expressed in low-invasive CL1-0 cells compared with isogenous high-invasive CL1-5 cells. duanyu1842NXA was preferably expressed in tumor tissues and associated with the prolonged survival of lung adenocarcinomas. duanyu1842NXA suppressed the invasion and metastasis of lung cancer cells in vitro and in vivo. By the expression microarray and pathway analysis, we found that the genes were enriched in the epithelial-mesenchymal transition (EMT) pathway. duanyu1842NXA reduced SNAI2 expression resulted in up-regulating E-cadherin. c-JUN acts as the positive-regulator of EMT. Silencing duanyu1842NXA increased c-JUN mRNA expression and blockage of c-JUN led to SNAI2 down-regulation. Our results clearly characterized duanyu1842NXA as an EMT inhibitor by suppressing c-JUN-SNAI2 axis in lung adenocarcinoma.

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