Mutations in ribosomal proteins: Apoptosis, cell competition, and cancer.

Mol Cell Oncol. 2015 May 07;3(1):e1029065. eCollection 2016 Jan

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摘要

Mutations affecting multiple ribosomal proteins are implicated in cancer. Using genetic mosaics in the fruit fly Drosophila, we describe 3 apoptotic mechanisms that affect Rp/Rp homozygous mutant cells, Rp/+ heterozygous cells, or Rp/+ heterozygous cells in competition with nearby wild type cells, and discuss how apoptosis might be related to cancer predisposition.

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Mutations in ribosomal proteins: Apoptosis, cell competition, and cancer.

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