GABARAP proteins as scaffolds in localized TIAM1-RAC1 signaling.

Mol Cell Oncol. 2015 Apr 14;3(1):e1027440. eCollection 2016 Jan

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Spatially restricted signaling is a hallmark of RAC1 signaling. Recent work has uncovered a novel role of gamma-aminobutyric acid receptor-associated proteins (GABARAPs), a subfamily of human ATG8 ubiquitin-like modifiers, in providing a scaffold for recruitment of an ubiquitin E3 ligase complex to its substrate, T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1), to enable ubiquitylation and thereby local control of RAC1 activity.

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GABARAP proteins as scaffolds in localized TIAM1-RAC1 signaling.

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