例如："lncRNA", "apoptosis", "WRKY"

Genome-Wide Association Study of Acute Renal Graft Rejection.

Am J Transplant. 2017 Jan;17(1):201-209. doi:10.1111/ajt.13912. Epub 2016 Jul 22
L Ghisdal 1 , C Baron 2 , Y Lebranchu 2 , O Viklický 3 , A Konarikova 3 , M Naesens 4 , D Kuypers 4 , M Dinic 5 , E Alamartine 5 , G Touchard 6 , T Antoine 6 , M Essig 7 , J P Rerolle 7 , P Merville 8 , J L Taupin 9 , Y Le Meur 10 , A Grall-Jezequel 10 , F Glowacki 11 , C Noël 11 , C Legendre 12 , D Anglicheau 12 , N Broeders 1 , W Coppieters 13 , E Docampo 13 , M Georges 13 , Z Ajarchouh 14 , A Massart 14 , J Racapé 15 , D Abramowicz 16 , M Abramowicz 17
L Ghisdal 1 , C Baron 2 , Y Lebranchu 2 , O Viklický 3 , A Konarikova 3 , M Naesens 4 , D Kuypers 4 , M Dinic 5 , E Alamartine 5 , G Touchard 6 , T Antoine 6 , M Essig 7 , J P Rerolle 7 , P Merville 8 , J L Taupin 9 , Y Le Meur 10 , A Grall-Jezequel 10 , F Glowacki 11 , C Noël 11 , C Legendre 12 , D Anglicheau 12 , N Broeders 1 , W Coppieters 13 , E Docampo 13 , M Georges 13 , Z Ajarchouh 14 , A Massart 14 , J Racapé 15 , D Abramowicz 16 , M Abramowicz 17
+ et al

[No authors listed]

Author information
  • 1 Department of Nephrology, Dialysis, and Transplantation, Hôpital Erasme (Université Libre de Bruxelles), Brussels, Belgium.
  • 2 Department of Nephrology, Centre Hospitalier Régional Universitaire de Tours, Tours, France.
  • 3 Department of Nephrology, Transplant Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
  • 4 Department of Nephrology, University Hospitals Leuven, Leuven, Belgium.
  • 5 Department of Nephrology, Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, France.
  • 6 Department of Nephrology, Centre Hospitalier Universitaire de Poitiers, Poitiers, France.
  • 7 Department of Nephrology, Dialysis, Transplantation, Centre Hospitalier Universitaire de Limoges and INSERM UMR 850 (Université de Limoges), Limoges, France.
  • 8 Department of Nephrology, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.
  • 9 Department of Immunology and Histocompatibility, Hôpital Saint-Louis, Paris, France.
  • 10 Department of Nephrology, Centre Hospitalier Universitaire la Cavale blanche, Brest, France.
  • 11 Department of Nephrology, Centre Régional Hospitalier Universitaire de Lille, Lille, France.
  • 12 Department of Renal Transplantation, Université Paris Descartes and Hôpital Necker, Assistance Publique-Hôpitaux de Paris, Paris, France.
  • 13 Unit of Animal Genomics, Groupe Interdisciplinaire de Génoprotéomique Appliquée-Research (GIGA-R), University of Liège, Liège, Belgium.
  • 14 Institute of Interdisciplinary Research in Molecular and Human biology (IRIBHM), Université Libre de Bruxelles, Brussels, Belgium.
  • 15 Centre of Epidemiology, Biostatistic and Clinical Research, School of Public Health (Université Libre de Bruxelles), Brussels, Belgium.
  • 16 Department of Nephrology, Antwerp University Hospital, Antwerpen, Belgium.
  • 17 Medical Genetics Department, Hôpital Erasme (Université Libre de Bruxelles), Brussels, Belgium.

摘要

Acute renal rejection is a major risk factor for chronic allograft dysfunction and long-term graft loss. We performed a genome-wide association study to detect loci associated with biopsy-proven acute T cell-mediated rejection occurring in the first year after renal transplantation. In a discovery cohort of 4127 European renal allograft recipients transplanted in eight European centers, we used a DNA pooling approach to compare 275 cases and 503 controls. In an independent replication cohort of 2765 patients transplanted in two European countries, we identified 313 cases and 531 controls, in whom we genotyped individually the most significant single nucleotide polymorphisms (SNPs) from the discovery cohort. In the discovery cohort, we found five candidate loci tagged by a number of contiguous SNPs (more than five) that was never reached in iterative in silico permutations of our experimental data. In the replication cohort, two loci remained significantly associated with acute rejection in both univariate and multivariate analysis. One locus encompasses PTPRO, coding for a receptor-type tyrosine kinase essential for B cell receptor signaling. The other locus involves ciliary gene CCDC67, in line with the emerging concept of a shared building design between the immune synapse and the primary cilium.

KEYWORDS: basic (laboratory) research/science, biomarker, genetics, genomics, immunogenetics, immunosuppression/immune modulation, kidney transplantation/nephrology, microarray/gene array, rejection: T cell mediated (TCMR)

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