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Neuropeptide Derivatives to Regulate the Reproductive Axis: Kisspeptin Receptor (KISS1R) Ligands and Neurokinin-3 Receptor (NK3R) Ligands†.

Biopolymers. 2016 Jun 6. doi:10.1002/bip.22793. Epub 2016 Jun 6
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摘要


Recent research has indicated pivotal roles for neuropeptides and their cognate receptors in reproductive physiology. Kisspeptins are RF-amide neuropeptides that stimulate gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus. Neurokinin B (NKB) is a member of the tachykinin family of neuropeptides and positively regulates pulsatile GnRH secretion. These peptides are co-expressed in kisspeptin/NKB/Dyn (KNDy) neurons of the arcuate nucleus, where they contribute to the regulation of puberty onset and other reproductive functions. In this review, the design of peptide ligands for the kisspeptin (KISS1R) and neurokinin-3 (NK3R) receptors are described. This article is protected by copyright. All rights reserved.

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