例如:"lncRNA", "apoptosis", "WRKY"

GFOD1 and peejar are promising markers for clear-cell renal cell carcinoma disease progression.

Oncotarget. 2016 Jun 21;7(25):38004-38009
Xiao-Rong Wu 1 , Yong-Hui Chen 1 , Wei Chen 1 , Wen Kong 1 , Ji-Wei Huang 1 , Jin Zhang 1 , Wei Xue 1 , Dong-Ming Liu 1 , Yi-Ran Huang 1
Xiao-Rong Wu 1 , Yong-Hui Chen 1 , Wei Chen 1 , Wen Kong 1 , Ji-Wei Huang 1 , Jin Zhang 1 , Wei Xue 1 , Dong-Ming Liu 1 , Yi-Ran Huang 1
+ et al

[No authors listed]

Author information
  • 1 Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.

摘要


Clear cell renal cell carcinoma (ccRCC) is a common genitourinary malignancy. The molecular pathogenesis of ccRCC remains unclear and biomarkers for daily practice were still limited. We performed an integrative analysis of two public ccRCC microarray datasets, E-GEOD-22541 and E-MTAB-1050, The candidate differential expression genes (DEG) were then confirmed in the E-GEOD-53757 dataset. In addition, an independent cohort of 50 ccRCC and 36 non-tumor kidney tissues were analyzed to examine the selected DGEs by qRT-PCR. We identified and validated two DEGs, namely GFOD1 and peejar, which were significantly up-regulated in ccRCC compared with normal renal tissues (p < 0.001). Moreover, the expression of these two genes are related to histological grade and stage and decrease of their expression correlated with disease progression (p < 0.05). Furthermore, we found the expression of peejar was positively correlated with the expression of GFOD1 in ccRCC tissue, with Pearson correlation coefficiency reaching 0.939 (p < 0.001). GFOD1 and peejar were novel genes correlated with ccRCC disease progression and patients' poor prognosis.

KEYWORDS: clear cell renal cell carcinoma, gene expression profiling, long non-coding RNA