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Hypomethylation of FAM63B in bipolar disorder patients.

Clin Epigenetics. 2016 May 11;8:52. eCollection 2016
Anna Starnawska 1 , Ditte Demontis 1 , Andrew McQuillin 2 , Niamh L O'Brien 2 , Nicklas H Staunstrup 3 , Ole Mors 4 , Anders L Nielsen 1 , Anders D Børglum 1 , Mette Nyegaard 1
Anna Starnawska 1 , Ditte Demontis 1 , Andrew McQuillin 2 , Niamh L O'Brien 2 , Nicklas H Staunstrup 3 , Ole Mors 4 , Anders L Nielsen 1 , Anders D Børglum 1 , Mette Nyegaard 1
+ et al

[No authors listed]

Author information
  • 1 Department of Biomedicine, Aarhus University, Wilhelm Meyers Alle 4, DK- 8000 Aarhus C, Denmark ; The Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark ; Center for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark.
  • 2 Molecular Psychiatry Laboratory, Division of Psychiatry, Rockefeller Building, University College London, London, UK.
  • 3 Department of Biomedicine, Aarhus University, Wilhelm Meyers Alle 4, DK- 8000 Aarhus C, Denmark ; The Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark ; Center for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark ; Translational Neuropsychiatry Unit, Aarhus University Hospital, Risskov, Denmark.
  • 4 The Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark ; Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark.
全文

摘要

Bipolar disorder (BD) and schizophrenia (SZ) are known to share common genetic and psychosocial risk factors. A recent epigenome-wide association study performed on blood samples from SZ patients found significant hypomethylation of FAM63B in exon 9. Here, we used iPLEX-based methylation analysis to investigate two CpG sites in FAM63B in blood samples from 459 BD cases and 268 controls. Both sites were significantly hypomethylated in BD cases (lowest p value = 3.94 × 10(-8)). The methylation levels at the two sites were correlated, and no strong correlation was found with nearby single nucleotide polymorphisms (SNPs), suggesting that methylation differences at these sites are not readably picked up by genome-wide association studies. Overall, FAM63B hypomethylation was found in BD patients, thus replicating the initial finding in SZ patients. This study suggests that FAM63B is a shared epigenetic risk gene for the two disorders.

KEYWORDS: Bipolar disorder, Candidate gene, DNA methylation, Epigenetics, FAM63B, Mental disorder, iPLEX

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