例如:"lncRNA", "apoptosis", "WRKY"

SLC35D3 increases autophagic activity in midbrain dopaminergic neurons by enhancing BECN1-ATG14-PIK3C3 complex formation.

Autophagy. 2016 Jul 02;12(7):1168-79. doi:10.1080/15548627.2016.1179402. Epub 2016 May 12
Zong-Bo Wei 1 , Ye-Feng Yuan 1 , Florence Jaouen 2 , Mei-Sheng Ma 3 , Chan-Juan Hao 4 , Zhe Zhang 5 , Quan Chen 6 , Zengqiang Yuan 7 , Li Yu 3 , Corinne Beurrier 2 , Wei Li 8
Zong-Bo Wei 1 , Ye-Feng Yuan 1 , Florence Jaouen 2 , Mei-Sheng Ma 3 , Chan-Juan Hao 4 , Zhe Zhang 5 , Quan Chen 6 , Zengqiang Yuan 7 , Li Yu 3 , Corinne Beurrier 2 , Wei Li 8
+ et al

[No authors listed]

Author information
  • 1 b University of Chinese Academy of Sciences , Beijing , China.
  • 2 c Aix-Marseille University, Center National de la Recherche Scientifique , UMR 7288 , Institut de Biologie du Développement de Marseille, Marseille , France.
  • 3 d School of Life Sciences, Tsinghua University , Beijing , China.
  • 4 e Center for Medical Genetics, Beijing Children's Hospital, Capital Medical University, Beijing Pediatric Research Institute , Beijing , China.
  • 5 a State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences , Beijing , China.
  • 6 f Institute of Zoology, Chinese Academy of Sciences , Beijing , China.
  • 7 g Institute of Biophysics, Chinese Academy of Sciences , Beijing , China.
  • 8 h Center of Alzheimer Disease, Beijing Institute for Brain Disorders , Beijing , China.

摘要


Searching for new regulators of autophagy involved in selective dopaminergic (DA) neuron loss is a hallmark in the pathogenesis of Parkinson disease (PD). We here report that an endoplasmic reticulum (ER)-associated transmembrane protein SLC35D3 is selectively expressed in subsets of midbrain DA neurons in about 10% TH (tyrosine hydroxylase)-positive neurons in the substantia nigra pars compacta (SNc) and in about 22% TH-positive neurons in the ventral tegmental area (VTA). Loss of SLC35D3 in ros (roswell mutant) mice showed a reduction of 11.9% DA neurons in the SNc and 15.5% DA neuron loss in the VTA with impaired autophagy. We determined that SLC35D3 enhanced the formation of the BECN1-ATG14-PIK3C3 complex to induce autophagy. These results suggest that SLC35D3 is a new regulator of tissue-specific autophagy and plays an important role in the increased autophagic activity required for the survival of subsets of DA neurons.

KEYWORDS: BECN1-ATG14-PIK3C3 complex, Parkinson disease, SLC35D3, autophagy, dopaminergic neuron, neurodegeneration