Two-pore Channels Enter the Atomic Era: Structure of Plant TPC Revealed.

Trends Biochem. Sci.2016 Jun;41(6):475-7. Epub 2016 May 04

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Two-pore channels (TPCs) are intracellular Ca(2+)-permeable ion channels that are expressed on acidic Ca(2+) stores. They are co-regulated by voltage and Ca(2+) in plant vacuoles and by the second messenger NAADP in animal endo-lysosomes. Two new studies of plant TPC structures reveal essential features of their architecture and provide mechanistic insight into their workings.

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Two-pore Channels Enter the Atomic Era: Structure of Plant TPC Revealed.

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