Cardiac ankyrin repeat protein not only serves as an important component of muscle sarcomere in the cytoplasm, but also acts as a transcription co-factor in the nucleus. Previous studies have demonstrated that is up-regulated in some cardiovascular disorders and muscle diseases; however, its role in these diseases remains controversial now. In this review, we will discuss the continued progress in the research related to including its discovery, structure, and the role it plays in cardiac development and heart diseases.
KEYWORDS: Cardiac ankyrin repeat protein (CARP), Cardiac development, Cardiovascular disease