A key requirement for CD300f in innate immune responses of eosinophils in colitis.
Mucosal Immunol. 2017 Jan;10(1):172-183. Epub 2016 Apr 27
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摘要
mice was accompanied with reduced inflammatory cell infiltration and nearly abolished production of pro-inflammatory cytokines. Monocyte depletion and chimeric bone marrow transfer experiments revealed a cell-specific requirement for CD300f in innate immune activation of eosinophils. Collectively, we uncover a new pathway regulating innate immune activities of eosinophils, a finding with significant implications in eosinophil-associated gastrointestinal diseases.
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文献解读
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