WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway.

FEBS Lett.2016 May;590(9):1291-303. doi:10.1002/1873-3468.12180. Epub 2016 May 03

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摘要

The stability of Î²-catenin is very important for canonical Wnt signaling. A protein complex including Axin/APC/GSK3Î² phosphorylates Î²-catenin to be degraded by ubiquitination with Î²-TrCP. In the recent study, we isolated WDR26, a protein that binds to Axin. Here, we found that WDR26 is a negative regulator of the canonical Wnt signaling pathway, and that WDR26 affected Î²-catenin levels. In addition, WDR26/Axin binding is involved in the ubiquitination of Î²-catenin. These results suggest that WDR26 plays a negative role in Î²-catenin degradation in the Wnt signaling pathway.

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WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway.

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