Regulation of Cancer Cell Behavior by the Small GTPase Rab13.
[No authors listed]
摘要
The members of the Rab family of GTPases are master regulators of cellular membrane trafficking. With â¼70 members in humans, Rabs have been implicated in all steps of membrane trafficking ranging from vesicle formation and transport to vesicle docking/tethering and fusion. Vesicle trafficking controls the localization and levels of a myriad of proteins, thus regulating cellular functions including proliferation, metabolism, cell-cell adhesion, and cell migration. It is therefore not surprising that impairment of Rab pathways is associated with diseases including cancer. In this review, we highlight evidence supporting the role of Rab13 as a potent driver of cancer progression.
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基因功能
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原始数据
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文献解读
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