Mammalian interspecies substitution of immune modulatory alleles by genome editing.
Sci Rep. 2016 Feb 22;6:21645
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摘要
We describe a fundamentally novel feat of animal genetic engineering: the precise and efficient substitution of an agronomic haplotype into a domesticated species. Zinc finger nuclease in-embryo editing of the RELA locus generated live born domestic pigs with the warthog RELA orthologue, associated with resilience to African Swine Fever. The ability to efficiently achieve interspecies allele introgression in one generation opens unprecedented opportunities for agriculture and basic research.
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基因功能
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原始数据
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文献解读
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