High PTPRQ Expression and Its Relationship to Expression of PTPRZ1 and the Presence of KRAS Mutations in Colorectal Cancer Tissues.

BACKGROUND:The risk of sporadic colorectal cancer (CRC) is strongly influenced by Iifestyle, environmental and genetic factors. Protein tyrosine phosphatases belong to a group of enzymes whose role in CRC has not yet been intensively studied. They play an important role in activation/de-activation of many enzymes, influencing cell biology by catalyzing reactions opposing those catalyzed by kinases. Protein tyrosine phosphatase receptor-like type Q and protein tyrosine phosphatase receptor-like type Z polypeptide 1 (PTPRZ1) have both been shown to be important in development of many cancer types including CRC. MATERIALS AND METHODS:The expression level of and PTPRZ1 was determined by real-time polymerase chain reaction in 16 CRC tissues obtained from patients diagnosed with adenocarcinoma coli. RESULTS:We revealed a high level of PTPduanyu1745 expression (p=0.0080), as well as an association between expression levels of PTPduanyu1745 and PTPRZ1 (p<0.0001). Moreover PTPduanyu1745 expression was higher in tissues presenting with Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation (p=0.0293). CONCLUSION:We confirmed the contribution of PTPRZ1 and especially PTPduanyu1745 in CRC development, supporting the hypothesis that PTPduanyu1745 is a candidate oncogene, playing a crucial role in phosphorylation/dephosphorylation signaling pathways.

KEYWORDS: {{ getKeywords(articleDetailText.words) }}