Dosage-dependent role of Rac1 in podocyte injury.
Am. J. Physiol. Renal Physiol.2016 Apr 15;310(8):F777-F784. Epub 2016 Jan 20
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摘要
, suggesting an adverse effect of Rac1 on slit diaphragm protein expression. Taken together, our data have demonstrated a causal link between excessive Rac1 activity and podocyte injury in a dosage-dependent manner, and transgenic zebrafish of variable Rac1 activities in podocytes may serve as useful animal models for the study of Rac1-related podocytopathy.
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文献解读
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