Interaction between the Spliceosomal Pre-mRNA Branch Site and U2 snRNP Protein p14.
Biochemistry. 2016 Feb 2;55(4):629-32. doi:10.1021/acs.biochem.5b01036. Epub 2016 Jan 25
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摘要
We have probed the molecular basis of recognition between human spliceosomal U2 snRNP protein p14 and RNA targets representing the intron branch site region. Interaction of an RNA duplex representing the branch site helix perturbed at least 10 nuclear magnetic resonance cross-peaks of (15)N-labeled p14. However, similar chemical shift changes were observed upon interaction with a duplex without the bulged branch site residue, suggesting that binding of p14 to RNA is nonspecific and does not recognize the branch site. We propose that the p14-RNA interaction screens charges on the backbone of the branch site during spliceosome assembly.
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基因功能
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原始数据
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文献解读
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