例如:"lncRNA", "apoptosis", "WRKY"

CCRL2 regulates M1/M2 polarization during EAE recovery phase.

J. Leukoc. Biol.2016 Jun;99(6):1027-33. Epub 2016 Jan 07
Cristina Mazzon 1 , Lucia Zanotti 2 , Li Wang 2 , Annalisa Del Prete 1 , Elena Fontana 3 , Valentina Salvi 3 , Pietro Luigi Poliani 3 , Silvano Sozzani 4
Cristina Mazzon 1 , Lucia Zanotti 2 , Li Wang 2 , Annalisa Del Prete 1 , Elena Fontana 3 , Valentina Salvi 3 , Pietro Luigi Poliani 3 , Silvano Sozzani 4
+ et al

[No authors listed]

Author information
  • 1 Department of Molecular and Translational Medicine, University of Brescia, Italy; and Humanitas Clinical and Research Center, Rozzano, Italy.
  • 2 Humanitas Clinical and Research Center, Rozzano, Italy.
  • 3 Department of Molecular and Translational Medicine, University of Brescia, Italy; and.
  • 4 Department of Molecular and Translational Medicine, University of Brescia, Italy; and Humanitas Clinical and Research Center, Rozzano, Italy silvano.sozzani@unibs.it.

摘要


Chemokine (CC motif) receptor-like 2 is a 7-transmembrane protein related to the family of the atypical chemokine receptors, which are proteins devoid of chemotactic activity and involved in the control of inflammation. Experimental autoimmune encephalitis is an autoimmune disorder that replicates the inflammatory aspects of multiple sclerosis. Chemokine (CC motif) receptor-like 2-deficient mice developed exacerbated, nonresolving disease with protracted inflammatory response and increased demyelination. The increased severity of the disease was associated with higher levels of microglia/macrophage activation markers and imbalanced M1/M2 polarization. Thus, chemokine (CC motif) receptor-like 2 is involved in the downregulation of central nervous system-associated experimental autoimmune encephalitis inflammation in the recovery phase of the disease. Therefore chemokine (CC motif) receptor-like 2 should be considered to be a molecule involved in the regulation of the inflammatory response associated with multiple sclerosis.

KEYWORDS: atypical chemokine receptors, chemokines, inflammation, macrophages, microglia, multiple sclerosis