BEND3 mediates transcriptional repression and heterochromatin organization.
Transcription. 2015;6(5):102-5. doi:10.1080/21541264.2015.1100228. Epub 2015 Oct 27
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摘要
Transcription repression plays a central role in gene regulation. Transcription repressors utilize diverse strategies to mediate transcriptional repression. We have recently demonstrated that BEND3 (BANP, E5R and Nac1 domain) protein represses rDNA transcription by stabilizing a NoRC component. We discuss the role of BEND3 as a global regulator of gene expression and propose a model whereby BEND3 associates with chromatin remodeling complexes to modulate gene expression and heterochromatin organization.
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基因功能
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原始数据
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文献解读
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