例如:"lncRNA", "apoptosis", "WRKY"

Expression of protein TARBP1 in human hepatocellular carcinoma and its prognostic significance.

Int J Clin Exp Pathol. 2015 Aug 01;8(8):9089-96. eCollection 2015
Jingmei Ye 1 , Jiani Wang 2 , Li Tan 3 , Shaojiang Yang 4 , Lihua Xu 3 , Xiaohong Wu 3 , Huaifu Deng 5 , Huo Tan 3
Jingmei Ye 1 , Jiani Wang 2 , Li Tan 3 , Shaojiang Yang 4 , Lihua Xu 3 , Xiaohong Wu 3 , Huaifu Deng 5 , Huo Tan 3
+ et al

[No authors listed]

Author information
  • 1 Department of Blood Transfusion, The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510230, China.
  • 2 Breast Cancer Center, The Third Affiliated Hospital of Sun Yat-sen University Guangzhou 510630, China.
  • 3 Department of Hematology, The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510230, China.
  • 4 Department of Hematology, The First People's Hospital of Foshan Foshan 528000, China.
  • 5 PET/CT Center, Department of Nuclear Medicine, The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510230, China.

摘要


OBJECTIVE:The objective of this study was to analyze the expression of TARBP1 and its clinical significance in hepatocellular carcinoma (HCC). MATERIALS AND METHODS:90 patients with primary hepatocellular carcinoma were included in this study. The tumor and paired adjacent non-tumor tissues were collected. TARBP1 expression was assessed by quantitative real-time polymerase chain reaction and immunohistochemistry. Associations of TARBP1 expression with the clinicopathological features were analyzed, and prognosis of HCC patients was evaluated. RESULTS:The result show the expression of TARBP1 mRNA in liver cancer tissues were higher than in the adjacent normal liver tissues in 10 paired samples (P=0.0015). Compared with adjacent normal liver tissues, overexpression of TARBP1 was detected in 61.1% (55/90) HCC patients. TARBP1 expression was associated with the AJCC tumor stage (P=0.004) and clinical stage (P=0.005), and decreased overall survival (P=0.002). In multivariate analysis, TARBP1 expression was an independent prognostic factor for overall survival (Hazard ratio [HR]=2.773, 95% confidence interval [CI] 1.542-4.985; P=0.019). CONCLUSIONS:TARBP1 is up-regulated in HCC, and the expression of TARBP1 was associated with the pathological grading and clinical stage. TARBP1 maybe is an independent prognostic marker of HCC patients.

KEYWORDS: Hepatocellular carcinoma-TARBP1- prognosis