Escherichia coli inner membrane protein YciB interacts with ZipA that is important for cell division.

Escherichia coli propagates by undergoing cycles of lateral elongation, septum formation, and cell fission at the mid-cell. A large number of genes involved in these processes have been identified, but it is likely that others remain. A deletion mutant of yciB (ΔyciB) is shorter in the cell length compared to wild type and, in contrast, over-expression of yciB causes elongation of the cell. Furthermore, the septum localization of ZipA, an essential protein of cell division, is disturbed in a ΔyciB mutant. Purified YciB protein directly interacted with ZipA, which might indicate that YciB is involved in the cell envelope synthesis directed by ZipA in a PBP3-independent manner.

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