Structural and functional analyses of the sixth site of neurexin alternative splicing.

Dokl. Biochem. Biophys.2015;463:239-42. doi:10.1134/S1607672915040110. Epub 2015 Sep 03

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In this study, we found the sixth site of alternative splicing (SS6) of neurexin 1a from the rat brain. This site is located between the fifth LNS and the third EGF-like domains. The insertion in the SS6 site corresponds to the 9-residue peptide VALMKADLQ, which is conserved among animals. We demonstrated that the SS6 insertion regulates tissue-specific expression of neurexin 1Î±.

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Structural and functional analyses of the sixth site of neurexin alternative splicing.

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