ITPKA expression is a novel prognostic factor in hepatocellular carcinoma.

BACKGROUND:Inositol-1,4,5-trisphosphate-3-kinase-A has recently been found to be implicated in the tumor progression of various cancers. However, the expression and the prognostic value of in hepatocellular carcinoma (HCC) remains unexplored. The aim of this study is to investigate the clinical significance of ITduanyu1529 expression in HCC. METHODS:We determined the expression level of ITduanyu1529 in 135 cases of HCC tissues and the matched adjacent nontumorous tissues by quantitative real-time RT-PCR. The correlation between ITduanyu1529 expression and prognosis of HCC patients was further evaluated by univariate and multivariate analysis. Multivariate analysis of the prognostic factors was performed with Cox proportional hazards model. RESULTS:Up-regulation of ITduanyu1529 occurred in 48.9% of primary HCCs compared with their nontumor counterparts (P < 0.001). In addition, high expression of ITduanyu1529 was significantly associated with vascular invasion (P = 0.001) and TNM stage (P = 0.005). Kaplan-Meier analysis showed that the 5-year overall survival (OS) and relapse-free survival (RFS) rate in the group with high expression of ITduanyu1529 is poorer than that in low expression group (32.2 and 26.8% versus 59.2 and 57.7%). Univariate and multivariate analyses revealed that ITduanyu1529 was an independent prognostic factor for OS and RFS. Moreover, Stratified analysis revealed that its prognostic significance still existed within the subgroup of patients with early clinical stage (TNM stage I) or normal serum AFP level (≤25 μg/L). CONCLUSION:Our data indicated that ITduanyu1529 expression was significantly up-regulated in HCC and could serve as a potential novel prognostic biomarker for HCC patients after surgery.

KEYWORDS: {{ getKeywords(articleDetailText.words) }}