例如:"lncRNA", "apoptosis", "WRKY"

RPS24 knockdown inhibits colorectal cancer cell migration and proliferation in vitro.

Gene. 2015 Oct 25;571(2):286-91. Epub 2015 Jul 03
Yue Wang 1 , Jinke Sui 2 , Xu Li 2 , Fuao Cao 2 , Jian He 2 , Bo Yang 1 , Xiaoming Zhu 2 , Yongsheng Sun 1 , Y D Pu 3
Yue Wang 1 , Jinke Sui 2 , Xu Li 2 , Fuao Cao 2 , Jian He 2 , Bo Yang 1 , Xiaoming Zhu 2 , Yongsheng Sun 1 , Y D Pu 3
+ et al

[No authors listed]

Author information
  • 1 Department of General Surgery, 309 Hospital of People's Liberation Army, 17 Heishanhu Road, Beijing, China.
  • 2 Department of Colorectal Surgery, Changhai Hospital, 168 Changhai Road, Shanghai, China.
  • 3 Department of General Surgery, 309 Hospital of People's Liberation Army, 17 Heishanhu Road, Beijing, China. Electronic address: ydpu2000@hotmail.com.

摘要


Besides new proteins synthesis, ribosomal protein has a role in extra-ribosomal functions, which are related to many diseases, such as Diamond-Blackfan anemia, hypoplasia, and cell apoptosis. However, the importance of RPS24 in human colon cancer is largely unknown. In this study, RPS24 gene expression was significantly inhibited in human colon cancer HCT116 and HT-29 cells using a lentivirus shRNA approach. Knockdown of RPS24 expression significantly inhibited cell proliferation, colony formation, cell migration and arrested cell in S phase. The results demonstrated for the first time that RPS24 gene had a critical role in human colon cancer. Therefore, our findings indicated that RPS24 gene may be a promising biomarker for therapy in human colon cancer and may have a potential application in the diagnosis or treatment of human colon cancer.

KEYWORDS: Cell cycle, Colon cancer, Migration, PS24, Proliferation

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