[No authors listed]
The aim of the present study was to investigate the expression levels of brainâspecific angiogenesis inhibitorâ1 (BAIâ1) in bladder transitional cell carcinoma (BTCC) at different stages and the mechanism by which it inhibits tumor endothelial cell proliferation. Normal bladder mucosa biopsy specimens were obtained as the control group, and human BTCC biopsy specimens were used as the study group. Immunohistochemical assays were used to detect the expression levels of BAIâ1, vascular endothelial growth factor (VEGF) and mutant p53, in addition to microvessel density (MVD) in the tissues. Western blotting was used to analyze the differential expression of BAIâ1 in the two samples. Statistical analysis was performed, which indicated that BAIâ1 expression levels in the normal bladder mucosa group were significantly higher than those in the BTCC group and were associated with clinical staging. BAIâ1 levels in the T1 stage BTCC tissues were higher than those in the T2â4 stage BTCC tissues (P<0.05). BAIâ1 expression levels were negatively correlated with those of VEGF (r=â0.661, P<0.001), mutant p53 (r=â0.406, P=0.002) and with the MVD (r=â0.675, P<0.001). BAIâ1 may be involved in the negative regulation of BTCC microvascular proliferation, and its expression may be associated with a reduction in p53 mutations.
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