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Investigation of TG gene variants and their effects on growth, carcass composition, and meat quality traits in Chinese steers.

Genet. Mol. Res.2015 May 22;14(2):5320-6
L P Zhang 1 , Q F Gan 2 , G Y Hou 3 , H J Gao 1 , J Y Li 4 , S Z Xu 1
L P Zhang 1 , Q F Gan 2 , G Y Hou 3 , H J Gao 1 , J Y Li 4 , S Z Xu 1
+ et al

[No authors listed]

Author information
  • 1 Key Laboratory for Farm Animal Genetic Resources and Utilization of Ministry of Agriculture of China, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China.
  • 2 College of Animal Science, Fujian Agricultural and Forestry University, Fuzhou, Fujian, China.
  • 3 Institute of Tropical Crop Genetic Resources, Chinese Academy of Tropical Agricultural Sciences, Danzhou, Hainan, China.
  • 4 Key Laboratory for Farm Animal Genetic Resources and Utilization of Ministry of Agriculture of China, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China JL1@iascaas.net.cn.

摘要


Thyroid hormones play an important role in regulating metabolism and can affect metabolism-related traits such as fat deposition. The thyroglobulin (TG) gene produces the precursor of thyroid hormones and has been proposed as a candidate gene for a quantitative trait locus with an effect on fat deposition. In this study, we identified 4 novel single nucleotide polymorphisms (SNPs) in the 5' flanking region of the TG gene using a DNA sequencing method. The SNP marker association analysis indicated that the T1355C SNPs were significantly associated with meat percentage (P < 0.05). A significant association between the G1356A polymorphism and live weight and loin muscle area was also detected (P < 0.05). However, no significant association was found between 4 SNPs and the other growth, carcass composition, and meat quality traits including intramuscular fat. The results of this study suggest that TG gene-specific SNPs may be a useful marker for growth traits in marker-assisted selection programs in beef cattle.

基因