[No authors listed]
An increasing number of studies have shown that microRNAs (miRNAs) are critical in tumor cell proliferation, as they modulate key gene transcripts. In the present study, the expression and roles of miRNA (miR)â802 were analyzed by quantitative polymerase chain reaction in breast cancer cells. The results showed that expression levels of miRâ802 were significantly reduced in breast cancer tissues and cells compared with those of normal tissue and normal breast epithelial cells. In vitro and in vivo experiments demonstrated that miRâ802 overexpression inhibited cell proliferation in MCFâ7 breast cancer cells and tumor growth in nude mice, respectively. Furthermore, mechanistic investigation with western blotting and luciferase reporter assays revealed that miRâ802 overexpression downregulated protein expression levels of Forkhead box protein M1 (FoxM1). Therefore, the results of the present study provided evidence for a previously undetermined miRâ802/FoxM1 molecular network, which was involved in the regulation of breast cancer cell proliferation.
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