Membrane bound O-acyltransferases and their inhibitors.

Biochem. Soc. Trans.2015 Apr;43(2):246-52

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Since the identification of the membrane-bound O-acyltransferase (MBOATs) protein family in the early 2000s, three distinct members [porcupine (PORCN), hedgehog (Hh) acyltransferase (HHAT) and ghrelin O-acyltransferase (GOAT)] have been shown to acylate specific proteins or peptides. In this review, topology determination, development of assays to measure enzymatic activities and discovery of small molecule inhibitors are compared and discussed for each of these enzymes.

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Membrane bound O-acyltransferases and their inhibitors.

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