例如:"lncRNA", "apoptosis", "WRKY"

Interleukin-19 acts as a negative autocrine regulator of activated microglia.

PLoS ONE. 2015 Mar 20;10(3):e0118640. eCollection 2015
Hiroshi Horiuchi 1 , Bijay Parajuli 1 , Yue Wang 1 , Yasu-Taka Azuma 2 , Tetsuya Mizuno 1 , Hideyuki Takeuchi 1 , Akio Suzumura 1
Hiroshi Horiuchi 1 , Bijay Parajuli 1 , Yue Wang 1 , Yasu-Taka Azuma 2 , Tetsuya Mizuno 1 , Hideyuki Takeuchi 1 , Akio Suzumura 1
+ et al

[No authors listed]

Author information
  • 1 Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan.
  • 2 Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Science, Izumisano, Osaka, 598-8531, Japan.
全文

摘要


Activated microglia can exert either neurotoxic or neuroprotective effects, and they play pivotal roles in the pathogenesis and progression of various neurological diseases. In this study, we used cDNA microarrays to show that interleukin-19 (IL-19), an IL-10 family cytokine, is markedly upregulated in activated microglia. Furthermore, we found that microglia are the only cells in the nervous system that express the IL-19 receptor, a heterodimer of the IL-20Rα and IL-20Rβ subunits. IL-19 deficiency increased the production of such pro-inflammatory cytokines as IL-6 and tumor necrosis factor-α in activated microglia, and IL-19 treatment suppressed this effect. Moreover, in a mouse model of Alzheimer's disease, we observed upregulation of IL-19 in affected areas in association with disease progression. Our findings demonstrate that IL-19 is an anti-inflammatory cytokine, produced by activated microglia, that acts negatively on microglia in an autocrine manner. Thus, microglia may self-limit their inflammatory response by producing the negative regulator IL-19.

基因