Receptor usage and cell entry of porcine epidemic diarrhea coronavirus.
J. Virol.2015 Jun;89(11):6121-5. Epub 2015 Mar 18
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摘要
Porcine epidemic diarrhea coronavirus (PEDV) has significantly damaged America's pork industry. Here we investigate the receptor usage and cell entry of PEDV. PEDV recognizes protein receptor aminopeptidase N from pig and human and sugar coreceptor N-acetylneuraminic acid. Moreover, PEDV infects cells from pig, human, monkey, and bat. These results support the idea of bats as an evolutionary origin for PEDV, implicate PEDV as a potential threat to other species, and suggest antiviral strategies to control its spread.
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基因功能
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原始数据
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文献解读
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