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High 18F-FDG uptake in PMAH correlated with normal expression of Glut1, HK1, HK2, and HK3.

Acta Radiol. 2016 Mar;57(3):370-7. Epub 2015 Mar 11
Isadora Pontes Cavalcante 1 , Maria Claudia Nogueira Zerbini 2 , Guilherme Asmar Alencar 3 , Beatriz de Paula Mariani 3 , Carlos Alberto Buchpiguel 4 , Madson Queiroz Almeida 5 , Berenice Bilharinho Mendonca 3 , Maria Candida Barisson Villares Fragoso 5
Isadora Pontes Cavalcante 1 , Maria Claudia Nogueira Zerbini 2 , Guilherme Asmar Alencar 3 , Beatriz de Paula Mariani 3 , Carlos Alberto Buchpiguel 4 , Madson Queiroz Almeida 5 , Berenice Bilharinho Mendonca 3 , Maria Candida Barisson Villares Fragoso 5
+ et al

[No authors listed]

Author information
  • 1 Unidade de Suprarrenal, Disciplina de Endocrinologia e Metabologia, Laboratório de Hormônios e Genética Molecular LIM42, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil isadoracavalcante@gmail.com.
  • 2 Departamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • 3 Unidade de Suprarrenal, Disciplina de Endocrinologia e Metabologia, Laboratório de Hormônios e Genética Molecular LIM42, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • 4 Serviço de Medicina Nuclear e Imagem Molecular do Instituto de Radiologia, São Paulo, Brazil.
  • 5 Unidade de Suprarrenal, Disciplina de Endocrinologia e Metabologia, Laboratório de Hormônios e Genética Molecular LIM42, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil Instituto do Cancer de Sao Paulo (ICESP), São Paulo, Brazil.

摘要

BACKGROUND:Primary macronodular adrenal hyperplasia (PMAH) is a rare cause of Cushing's syndrome, characterized by functioning adrenal macronodules and variable cortisol production. Recently, we demonstrated a high 18F-FDG uptake in PMAH, an unexpected finding for a benign disorder. PURPOSE:To investigate whether there is a correlation between 18F-FDG high uptake and the expression levels of the glycolytic pathway components GLUT1, HK1, HK2, and HK3 in PMAH. MATERIAL AND METHODS:We selected 12 patients undergoing surgery for PMAH who had preoperatively undergone 18F-FDG PET/CT. mRNA and protein expression of the selected genes were evaluated in the adrenal nodules from patients who underwent surgery through quantitative RT-PCR and by immunohistochemistry, respectively. RESULTS:SUVmax in PMAH was in the range of 3.3-8.9 and the adrenal size was in the range of 3.5-15 cm. A strong correlation between 18F-FDG uptake and largest adrenal diameter was observed in patients with PMAH. However, no correlation between 18F-FDG uptake and GLUT1, HK1, HK2, HK3 mRNA, and protein expression was observed. CONCLUSION:High 18F-FDG uptake is observed in the majority of PMAH cases. However, 18F-FDG uptake in PMAH is independent of the expression levels of GLUT1, HK1, HK2, and HK3. Further investigation is required to elucidate the molecular mechanisms underlying increased 18F-FDG uptake in PMAH.

KEYWORDS: 18F-FDG, Cushing’s syndrome, PET, Primary macronodular adrenal hyperplasia, adrenal, adults, hyperplasia, monoclonal antibodies

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